SrasV1, Main, Exploration, bibRecord, 001993

Animal models for highly pathogenic emerging viruses.

Identifieur interne : 001993 ( Main/Exploration ); précédent : 001992; suivant : 001994

Animal models for highly pathogenic emerging viruses.

Auteurs : David Safronetz [États-Unis] ; Thomas W. Geisbert ; Heinz Feldmann

Source :

Current opinion in virology [ 1879-6265 ] ; 2013.

RBID : pubmed:23403208

Descripteurs français

KwdFr :
- Animaux, Humains, Maladies transmissibles émergentes (virologie), Maladies virales (virologie), Modèles animaux de maladie humaine.
MESH :
- virologie : Maladies transmissibles émergentes, Maladies virales.
- Animaux, Humains, Modèles animaux de maladie humaine.

English descriptors

KwdEn :
- Animals, Communicable Diseases, Emerging (virology), Disease Models, Animal, Humans, Virus Diseases (virology).
MESH :
- virology : Communicable Diseases, Emerging, Virus Diseases.
- Animals, Disease Models, Animal, Humans.

Abstract

Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East. The sporadic nature of these infections hampers our understanding of these diseases and limits the opportunities to design appropriate medical countermeasures against them. Because of this, animal models are utilized to gain insight into the pathogenesis of disease with the overall goal of identifying potential targets for intervention and evaluating specific therapeutics and vaccines. For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. In this article we review the current status of disease models for highly pathogenic and emerging viral pathogens.

DOI: 10.1016/j.coviro.2013.01.001
PubMed: 23403208

Affiliations:

Le document en format XML

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<author><name sortKey="Safronetz, David" sort="Safronetz, David" uniqKey="Safronetz D" first="David" last="Safronetz">David Safronetz</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT</wicri:regionArea>
<placeName><region type="state">Montana</region>
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<author><name sortKey="Geisbert, Thomas W" sort="Geisbert, Thomas W" uniqKey="Geisbert T" first="Thomas W" last="Geisbert">Thomas W. Geisbert</name>
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<author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name>
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<author><name sortKey="Geisbert, Thomas W" sort="Geisbert, Thomas W" uniqKey="Geisbert T" first="Thomas W" last="Geisbert">Thomas W. Geisbert</name>
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<series><title level="j">Current opinion in virology</title>
<idno type="eISSN">1879-6265</idno>
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<term>Humans</term>
<term>Virus Diseases (virology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Maladies transmissibles émergentes (virologie)</term>
<term>Maladies virales (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies transmissibles émergentes</term>
<term>Maladies virales</term>
</keywords>
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<term>Virus Diseases</term>
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<term>Disease Models, Animal</term>
<term>Humans</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en">Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East. The sporadic nature of these infections hampers our understanding of these diseases and limits the opportunities to design appropriate medical countermeasures against them. Because of this, animal models are utilized to gain insight into the pathogenesis of disease with the overall goal of identifying potential targets for intervention and evaluating specific therapeutics and vaccines. For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. In this article we review the current status of disease models for highly pathogenic and emerging viral pathogens.</div>
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<country name="États-Unis"><region name="Montana"><name sortKey="Safronetz, David" sort="Safronetz, David" uniqKey="Safronetz D" first="David" last="Safronetz">David Safronetz</name>
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Serveur d'exploration SRAS

Animal models for highly pathogenic emerging viruses.

Animal models for highly pathogenic emerging viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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